Title : Reprogramming of mitochondrial proline metabolism promotes liver tumorigenesis.

Pub. Date : 2021 Dec

PMID : 33646427






2 Functional Relationships(s)
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1 Two of the enzymes in the proline biosynthetic pathway, pyrroline-5-carboxylate reductase (PYCR1) and Aldehyde Dehydrogenase 18 Family Member A1 (ALDH18A1), are upregulated in liver cancer of both human and animal models, while proline catabolic enzymes, such as proline dehydrogenase (PRODH) are downregulated. Proline pyrroline-5-carboxylate reductase 1 Homo sapiens
2 Two of the enzymes in the proline biosynthetic pathway, pyrroline-5-carboxylate reductase (PYCR1) and Aldehyde Dehydrogenase 18 Family Member A1 (ALDH18A1), are upregulated in liver cancer of both human and animal models, while proline catabolic enzymes, such as proline dehydrogenase (PRODH) are downregulated. Proline pyrroline-5-carboxylate reductase 1 Homo sapiens