Title : mTOR inhibition as a possible pharmacological target in the management of systemic inflammatory response and associated neuroinflammation by lipopolysaccharide challenge in rats.

Pub. Date : 2021 Sep

PMID : 33641344






1 Functional Relationships(s)
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1 Inhibition of mTOR by rapamycin blocked phosphorylated form of ribosomal protein S6, NF-kappaB p65 activity by increasing degradation of IkappaB-alpha in parallel with HIF-1alpha expression increased by LPS in the kidney, heart, lung, and brain tissues. Sirolimus mechanistic target of rapamycin kinase Rattus norvegicus