Pub. Date : 2021 Dec
PMID : 33632062
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Andrographolide emeliorates maltol aluminium-induced neurotoxicity via regulating p62-mediated Keap1-Nrf2 pathways in PC12 cells. | andrographolide | Kelch-like ECH-associated protein 1 | Rattus norvegicus |
| 2 | OBJECTIVE: The efficacy of Andro on p62-mediated Kelch-like ECH-associated protein 1(Keap1)-Nuclear factor E2 related factor 2 (Nrf2) pathways in the aluminium maltolate (Al(mal)3)-induced neurotoxicity in PC12 cell was explored. | andrographolide | Kelch-like ECH-associated protein 1 | Rattus norvegicus |
| 3 | Furthermore, Nrf2 and p62 nuclear translocation were increased and keap1 in the cytoplasm was decreased in the presence of Andro. | andrographolide | Kelch-like ECH-associated protein 1 | Rattus norvegicus |
| 4 | DISCUSSION AND CONCLUSIONS: Our results suggested that Andro could be a promising therapeutic lead against Al-induced neurotoxicity by regulating p62-mediated keap1-Nrf2 pathways. | andrographolide | Kelch-like ECH-associated protein 1 | Rattus norvegicus |