Title : 4β-Hydroxycholesterol is a prolipogenic factor that promotes SREBP1c expression and activity through the liver X receptor.

Pub. Date : 2021

PMID : 33631213






3 Functional Relationships(s)
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1 By correlating tracing of lipid synthesis with lipogenic gene expression profiling, we found that 4beta-HC acts as a putative agonist for Liver X receptor (LXR), a sterol sensor and transcriptional regulator previously linked to SREBP1c activation. cholest-5-ene-3,4-diol nuclear receptor subfamily 1, group H, member 3 Mus musculus
2 By correlating tracing of lipid synthesis with lipogenic gene expression profiling, we found that 4beta-HC acts as a putative agonist for Liver X receptor (LXR), a sterol sensor and transcriptional regulator previously linked to SREBP1c activation. cholest-5-ene-3,4-diol nuclear receptor subfamily 1, group H, member 3 Mus musculus
3 Thus, 4beta-HC is an endogenous regulator of de novo lipogenesis through the LXR-SREBP1c axis. cholest-5-ene-3,4-diol nuclear receptor subfamily 1, group H, member 3 Mus musculus