Pub. Date : 2021
PMID : 33631213
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | By correlating tracing of lipid synthesis with lipogenic gene expression profiling, we found that 4beta-HC acts as a putative agonist for Liver X receptor (LXR), a sterol sensor and transcriptional regulator previously linked to SREBP1c activation. | cholest-5-ene-3,4-diol | nuclear receptor subfamily 1, group H, member 3 | Mus musculus |
| 2 | By correlating tracing of lipid synthesis with lipogenic gene expression profiling, we found that 4beta-HC acts as a putative agonist for Liver X receptor (LXR), a sterol sensor and transcriptional regulator previously linked to SREBP1c activation. | cholest-5-ene-3,4-diol | nuclear receptor subfamily 1, group H, member 3 | Mus musculus |
| 3 | Thus, 4beta-HC is an endogenous regulator of de novo lipogenesis through the LXR-SREBP1c axis. | cholest-5-ene-3,4-diol | nuclear receptor subfamily 1, group H, member 3 | Mus musculus |