Title : Molecular mechanism study of BPAF-induced proliferation of ERĪ±-negative SKBR-3 human breast cancer cells in vitro/in vivo.

Pub. Date : 2021 Jun 25

PMID : 33621883






2 Functional Relationships(s)
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1 Low concentrations of BPAF markedly increased the expression of G protein-coupled estrogen receptor (GPER1), c-Myc, CyclinD1 and c-Fos proteins, and enhanced phosphorylation of extracellular signal-regulated kinase (Erk) and protein kinase B (Akt) in SKBR-3 cells. 4,4'-hexafluorisopropylidene diphenol G protein-coupled estrogen receptor 1 Homo sapiens
2 The findings showed that GPER1 could independently regulate BPAF-induced proliferation of SKBR-3 cells without requiring ERalpha. 4,4'-hexafluorisopropylidene diphenol G protein-coupled estrogen receptor 1 Homo sapiens