Title : Stress increases blood beta-hydroxybutyrate levels and prefrontal cortex NLRP3 activity jointly in a rodent model.

Pub. Date : 2021 Jun

PMID : 33609086






4 Functional Relationships(s)
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1 AIM: This study aimed to assess the response of endogenous beta-hydroxybutyrate to psychological stress, and its association with nucleotide-binding domain, leucine-rich repeat, pyrin domain-containing 3 (NLRP3) inflammasome, and stress-induced behavior. 3-Hydroxybutyric Acid NLR family, pyrin domain containing 3 Mus musculus
2 A correlation was found between the increased beta-hydroxybutyrate levels in the blood and the active NLRP3 levels in the prefrontal cortex. 3-Hydroxybutyric Acid NLR family, pyrin domain containing 3 Mus musculus
3 CONCLUSIONS: The increased blood beta-hydroxybutyrate levels due to psychological stress correlate with the active NLRP3 levels in the prefrontal cortex, suggesting that the increased beta-hydroxybutyrate levels due to stress may reflect a reaction to brain inflammation. 3-Hydroxybutyric Acid NLR family, pyrin domain containing 3 Mus musculus
4 CONCLUSIONS: The increased blood beta-hydroxybutyrate levels due to psychological stress correlate with the active NLRP3 levels in the prefrontal cortex, suggesting that the increased beta-hydroxybutyrate levels due to stress may reflect a reaction to brain inflammation. 3-Hydroxybutyric Acid NLR family, pyrin domain containing 3 Mus musculus