Title : DEC1 deficiency results in accelerated osteopenia through enhanced DKK1 activity and attenuated PI3KCA/Akt/GSK3β signaling.

Pub. Date : 2021 May

PMID : 33607194






1 Functional Relationships(s)
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1 These changes, however, were reversed by in vivo treatment with lithium chloride, a stabilizer of beta-catenin, and confirmed by gain-of-function study with DEC1 transfection into DEC1 KO bone marrow mesenchymal stem cells and loss-of-function study with siDEC1 lentiviral infection into the corresponding WT cells. Lithium Chloride catenin (cadherin associated protein), beta 1 Mus musculus