Title : Kynurenine 3-monooxygenase deficiency induces depression-like behavior via enhanced antagonism of α7 nicotinic acetylcholine receptors by kynurenic acid.

Pub. Date : 2021 May 7

PMID : 33607168






2 Functional Relationships(s)
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1 Methyllycaconitine (an alpha7nAChR antagonist) antagonized the effect of nicotine on decreased social interaction time and prolonged immobility in the forced swimming test, but not increased locomotor activity. Nicotine cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus
2 The ameliorating effects of nicotine and galantamine on depression-like behaviors in KMO KO mice are associated with the activation of alpha7nAChR. Nicotine cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus