Title : Simvastatin and ROCK Inhibitor Y-27632 Inhibit Myofibroblast Differentiation of Graves' Ophthalmopathy-Derived Orbital Fibroblasts via RhoA-Mediated ERK and p38 Signaling Pathways.

Pub. Date : 2020

PMID : 33597925






2 Functional Relationships(s)
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1 Both simvastatin and Y-27632 inhibited TGF-beta-induced alpha-smooth muscle actin (alpha-SMA) expression, which serves as a marker of fibrosis. Simvastatin actin alpha 1, skeletal muscle Homo sapiens
2 The inhibitory effect of simvastatin on TGF-beta-induced RhoA, ROCK1, and alpha-SMA expression could be reversed by geranylgeranyl pyrophosphate, an intermediate in the biosynthesis of cholesterol. Simvastatin actin alpha 1, skeletal muscle Homo sapiens