Title : Simvastatin and ROCK Inhibitor Y-27632 Inhibit Myofibroblast Differentiation of Graves' Ophthalmopathy-Derived Orbital Fibroblasts via RhoA-Mediated ERK and p38 Signaling Pathways.

Pub. Date : 2020

PMID : 33597925






3 Functional Relationships(s)
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1 Simvastatin and ROCK Inhibitor Y-27632 Inhibit Myofibroblast Differentiation of Graves" Ophthalmopathy-Derived Orbital Fibroblasts via RhoA-Mediated ERK and p38 Signaling Pathways. Simvastatin mitogen-activated protein kinase 1 Homo sapiens
2 Furthermore, simvastatin and Y-27632 suppressed TGF-beta-induced phosphorylation of ERK and p38. Simvastatin mitogen-activated protein kinase 1 Homo sapiens
3 These results suggested that simvastatin inhibits TGF-beta-induced myofibroblast differentiation via suppression of the RhoA/ROCK/ERK and p38 MAPK signaling pathways. Simvastatin mitogen-activated protein kinase 1 Homo sapiens