Title : Anti-malarial and cytokine-modulating effects of andrographolide in a murine model of malarial infection.

Pub. Date : 2019 Sep 1

PMID : 33597499






2 Functional Relationships(s)
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1 Western blot analyses revealed that andrographolide treatment of P. berghei NK65-infected mice resulted in an increased level of phosphorylated GSK3beta (Ser9) in liver of infected mice. andrographolide glycogen synthase kinase 3 alpha Mus musculus
2 Taken together, our findings demonstrate that the cytokine-modulating effect of andrographolide in experimental malarial infection involves at least in part inhibition of NF-kappaB activation as a consequence of GSK3beta inhibition. andrographolide glycogen synthase kinase 3 alpha Mus musculus