Title : Aspirin eugenol ester ameliorates paraquat-induced oxidative damage through ROS/p38-MAPK-mediated mitochondrial apoptosis pathway.

Pub. Date : 2021 Apr 15

PMID : 33592258






2 Functional Relationships(s)
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1 In vitro, A549 cells were treated with 250 microM PQ for 24 h. Incubation of A549 cells with PQ led to apoptosis, and increased the level of superoxide anions, reactive oxygen species (ROS), malondialdehyde and the activity of caspase-3 and up-regulation of phosphorylated p38-MAPK, reduced mitochondrial membrane potential (DeltaPsim) and the activity of SOD. Paraquat caspase 3 Rattus norvegicus
2 In vitro, A549 cells were treated with 250 microM PQ for 24 h. Incubation of A549 cells with PQ led to apoptosis, and increased the level of superoxide anions, reactive oxygen species (ROS), malondialdehyde and the activity of caspase-3 and up-regulation of phosphorylated p38-MAPK, reduced mitochondrial membrane potential (DeltaPsim) and the activity of SOD. Paraquat caspase 3 Rattus norvegicus