Title : Xanthone: Potential Acetylcholinesterase Inhibitor for Alzheimer's Disease Treatment.

Pub. Date : 2021

PMID : 33583373






3 Functional Relationships(s)
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1 Naturally occurring xanthones, including oxygenated, prenylated, pyrano and glycosylated xanthones exhibited promising inhibition effects towards acetylcholinesterase. Xanthones acetylcholinesterase (Cartwright blood group) Homo sapiens
2 Naturally occurring xanthones, including oxygenated, prenylated, pyrano and glycosylated xanthones exhibited promising inhibition effects towards acetylcholinesterase. Xanthones acetylcholinesterase (Cartwright blood group) Homo sapiens
3 Structure-activity relationship of xanthones revealed that the type and position of substituent(s) attached to the xanthone moiety influenced their acetylcholinesterase inhibition activities where hydrophobic moiety will lead to an improved activity by contributing the pi-pi interactions, as well as the hydroxy substituent(s) by forming hydrogen-bond interactions. Xanthones acetylcholinesterase (Cartwright blood group) Homo sapiens