Title : Network Meta-Analysis on the Mechanisms Underlying Alcohol Augmentation of COVID-19 Pathologies.

Pub. Date : 2021 Apr

PMID : 33583045






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1 Our network meta-analysis suggests that EtOH exposure may augment the effects of SARS-CoV-2 infection on hepatic fibrosis signaling pathway, cellular metabolism and homeostasis, inflammation, and neuroinflammation, and that EtOH may enhance the activity of key meditators including cytokines, such as IL1beta, IL6, and TNF, and transcription factors, such as JUN and STAT, while inhibiting the activity of anti-inflammatory mediators including glucocorticoid receptor. Ethanol interleukin 6 Homo sapiens