Title : The relationship of embryotoxicity to disposition of 2-methoxyethanol in mice.

Pub. Date : 1988 Apr

PMID : 3358259






1 Functional Relationships(s)
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1 The ADH inhibitor 4-methylpyrazole (0.12 or 1.2 mmol/kg) or ethanol (43.3 mmol/kg, single dose concomitant with ME or additional ethanol 5 and 10 hr later) reduced the incidence of malformations 60-100%, depending on the dosing regimen. Fomepizole aldo-keto reductase family 1, member A1 (aldehyde reductase) Mus musculus