Pub. Date : 2021 Feb 12
PMID : 33579943
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | EGCG binds intrinsically disordered N-terminal domain of p53 and disrupts p53-MDM2 interaction. | epigallocatechin gallate | tumor protein p53 | Homo sapiens |
| 2 | EGCG binds intrinsically disordered N-terminal domain of p53 and disrupts p53-MDM2 interaction. | epigallocatechin gallate | tumor protein p53 | Homo sapiens |
| 3 | Using SPR and NMR, here we report a direct, muM interaction between EGCG and the tumor suppressor p53 (KD = 1.6 +- 1.4 muM), with the disordered N-terminal domain (NTD) identified as the major binding site (KD = 4 +- 2 muM). | epigallocatechin gallate | tumor protein p53 | Homo sapiens |
| 4 | The EGCG-p53 interaction disrupts p53 interaction with its regulatory E3 ligase MDM2 and inhibits ubiquitination of p53 by MDM2 in an in vitro ubiquitination assay, likely stabilizing p53 for anti-tumor activity. | epigallocatechin gallate | tumor protein p53 | Homo sapiens |
| 5 | The EGCG-p53 interaction disrupts p53 interaction with its regulatory E3 ligase MDM2 and inhibits ubiquitination of p53 by MDM2 in an in vitro ubiquitination assay, likely stabilizing p53 for anti-tumor activity. | epigallocatechin gallate | tumor protein p53 | Homo sapiens |
| 6 | The EGCG-p53 interaction disrupts p53 interaction with its regulatory E3 ligase MDM2 and inhibits ubiquitination of p53 by MDM2 in an in vitro ubiquitination assay, likely stabilizing p53 for anti-tumor activity. | epigallocatechin gallate | tumor protein p53 | Homo sapiens |
| 7 | The EGCG-p53 interaction disrupts p53 interaction with its regulatory E3 ligase MDM2 and inhibits ubiquitination of p53 by MDM2 in an in vitro ubiquitination assay, likely stabilizing p53 for anti-tumor activity. | epigallocatechin gallate | tumor protein p53 | Homo sapiens |
| 8 | Our work provides insights into the mechanisms for EGCG"s anticancer activity and identifies p53 NTD as a target for cancer drug discovery through dynamic interactions with small molecules. | epigallocatechin gallate | tumor protein p53 | Homo sapiens |