Title : FK866 Protects Human Dental Pulp Cells against Oxidative Stress-Induced Cellular Senescence.

Pub. Date : 2021 Feb 10

PMID : 33578781






1 Functional Relationships(s)
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1 Moreover, the stimulatory effects of H2O2 on cellular senescence are associated with oxidative stress induction, such as excessive ROS production and NADPH consumption, telomere DNA damage induction, and upregulation of senescence-associated secretory phenotype factors (IL-1beta, IL-6, IL-8, COX-2, and TNF-alpha) as well as NF-kappaB activation, which were all blocked by FK866. Hydrogen Peroxide nuclear factor kappa B subunit 1 Homo sapiens