Title : Ribavirin inhibits colorectal cancer growth by downregulating PRMT5 expression and H3R8me2s and H4R3me2s accumulation.

Pub. Date : 2021 Mar 15

PMID : 33577917






2 Functional Relationships(s)
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1 Mechanistically, Ribavirin treatment significantly reduced PRMT5 and eIF4E protein levels and the accumulation of symmetric dimethylation of histone 3 at arginine 8 (H3R8me2s) and that of histone 4 at arginine 3 (H4R3me2s). Ribavirin eukaryotic translation initiation factor 4E Mus musculus
2 Importantly, inhibition of PRMT5 by ribavirin resulted in promoted H3R8 methylation in eIF4E promoter region. Ribavirin eukaryotic translation initiation factor 4E Mus musculus