Pub. Date : 2021 May
PMID : 33576879
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Niacin stimulates EPH4EV mammary epithelial cell proliferation and mammary gland development in pubertal mice through activation of AKT/mTOR and ERK1/2 signaling pathways. | Niacin | thymoma viral proto-oncogene 1 | Mus musculus |
| 2 | The results showed that niacin could activate the AKT/mTOR and ERK signaling pathways and increase phosphorylation of 4EBP1 to promote the synthesis of cell proliferation markers, leading to the dissociation of the Rb-E2F1 complex in mMECs. | Niacin | thymoma viral proto-oncogene 1 | Mus musculus |
| 3 | In addition, 0.5% niacin promoted mammary duct development, increased the expression of cyclin D1/D3 and PCNA and activated Akt/mTOR and ERK1/2 in the mammary glands of pubertal mice. | Niacin | thymoma viral proto-oncogene 1 | Mus musculus |
| 4 | These results strongly suggest that niacin stimulates mammary gland development in pubertal mice through the Akt/mTOR and ERK1/2 signaling pathways. | Niacin | thymoma viral proto-oncogene 1 | Mus musculus |