Title : siRNA Knockdown of REDD1 Facilitates Aspirin-Mediated Dephosphorylation of mTORC1 Target 4E-BP1 in MDA-MB-468 Human Breast Cancer Cell Line.

Pub. Date : 2021

PMID : 33574709






1 Functional Relationships(s)
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1 Inhibition of mTORC1 (mechanistic target of rapamycin complex 1) activity upon aspirin treatment has been reported in breast cancer cells harboring PI3KCA (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) mutation and is considered to account for anticancer action. Aspirin phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Homo sapiens