Title : Inhibition of HER Receptors Reveals Distinct Mechanisms of Compensatory Upregulation of Other HER Family Members: Basis for Acquired Resistance and for Combination Therapy.

Pub. Date : 2021 Jan 29

PMID : 33572976






2 Functional Relationships(s)
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1 In a tumor cell line xenograft mouse model, therapeutic intervention with nanoscale complexes based on polyethylenimine (PEI) for siRNA delivery, again reveals HER3 upregulation upon HER2 single knockdown and a therapeutic benefit from combination therapy. Polyethyleneimine erb-b2 receptor tyrosine kinase 2 Mus musculus
2 In a tumor cell line xenograft mouse model, therapeutic intervention with nanoscale complexes based on polyethylenimine (PEI) for siRNA delivery, again reveals HER3 upregulation upon HER2 single knockdown and a therapeutic benefit from combination therapy. Polyethyleneimine erb-b2 receptor tyrosine kinase 2 Mus musculus