Pub. Date : 2021 Feb 5
PMID : 33562835
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Polyphyllin D Shows Anticancer Effect through a Selective Inhibition of Src Homology Region 2-Containing Protein Tyrosine Phosphatase-2 (SHP2). | polyphyllin D | protein tyrosine phosphatase non-receptor type 11 | Homo sapiens |
| 2 | Polyphyllin D was found to selectively inhibit SHP2 over SHP1, whereas two other identified compounds (echinocystic acid and oleanolic acid) demonstrated dual SHP1 and SHP2 inhibition. | polyphyllin D | protein tyrosine phosphatase non-receptor type 11 | Homo sapiens |
| 3 | These results demonstrated that polyphyllin D has potential anticancer activity, which can be attributed to its selective inhibition of SHP2 over SHP1. | polyphyllin D | protein tyrosine phosphatase non-receptor type 11 | Homo sapiens |