Pub. Date : 2021 Feb 7
PMID : 33562281
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Exogenous NAD+ Postpones the D-Gal-Induced Senescence of Bone Marrow-Derived Mesenchymal Stem Cells via Sirt1 Signaling. | NAD | sirtuin 1 | Homo sapiens |
| 2 | Further investigation showed that exogenous NAD+ weakened BMSC senescence by increasing Sirtuin 1 (Sirt1) expression. | NAD | sirtuin 1 | Homo sapiens |
| 3 | Further investigation showed that exogenous NAD+ weakened BMSC senescence by increasing Sirtuin 1 (Sirt1) expression. | NAD | sirtuin 1 | Homo sapiens |
| 4 | In addition, the reduced expression of Sirt1 by small interfering RNA abolished the beneficial effects of exogenous NAD+ in terms of postponing BMSCs senescence induced by D-gal. | NAD | sirtuin 1 | Homo sapiens |
| 5 | Taken together, our results indicate that exogenous NAD+ could postpone D-gal-induced BMSC senescence through Sirt1 signaling, providing a potential method for obtaining high quality BMSCs to support their research and clinical application. | NAD | sirtuin 1 | Homo sapiens |