Pub. Date : 2021 May
PMID : 33558100
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here we evaluate ELX-02 mediated read-through using the CFTR-dependent Forskolin-induced swelling (FIS) assay across a selection of G542X genotype patient derived organoids (PDOs). | Colforsin | CF transmembrane conductance regulator | Homo sapiens |
| 2 | RESULTS: PDOs homozygous for G542X or heterozygous with a second minimally functional allele had significantly increased CFTR activity with ELX-02 in a dose-dependent fashion across a variety of forskolin induction concentrations. | Colforsin | CF transmembrane conductance regulator | Homo sapiens |