Pub. Date : 2021 Feb 5
PMID : 33546773
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this study, we hypothesized that glucose uptake and glycolysis increase in testosterone-treated cardiomyocytes through AMPK and androgen receptor (AR). | Testosterone | androgen receptor | Rattus norvegicus |
| 2 | In this study, we hypothesized that glucose uptake and glycolysis increase in testosterone-treated cardiomyocytes through AMPK and androgen receptor (AR). | Testosterone | androgen receptor | Rattus norvegicus |
| 3 | In addition, testosterone increased AMPK phosphorylation (Thr172), while inhibition of both AMPK and AR blocked glycolysis and cardiomyocyte hypertrophy induced by testosterone. | Testosterone | androgen receptor | Rattus norvegicus |
| 4 | CONCLUSION: These results indicate that testosterone stimulates glucose metabolism by activation of AMPK and AR signaling which are critical to induce cardiomyocyte hypertrophy. | Testosterone | androgen receptor | Rattus norvegicus |