Title : Endothelial-transcytosed myeloperoxidase activates endothelial nitric oxide synthase via a phospholipase C-dependent calcium signaling pathway.

Pub. Date : 2021 Apr

PMID : 33539947






4 Functional Relationships(s)
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1 In the presence of chloride ions and hydrogen peroxide (H2O2), MPO forms the oxidant hypochlorous acid (HOCl). Hypochlorous Acid myeloperoxidase Homo sapiens
2 In the presence of chloride ions and hydrogen peroxide (H2O2), MPO forms the oxidant hypochlorous acid (HOCl). Hypochlorous Acid myeloperoxidase Homo sapiens
3 Here we examined the short-term implications of HOCl produced by endothelial-transcytosed MPO for eNOS activity. Hypochlorous Acid myeloperoxidase Homo sapiens
4 Exposure of MPO-containing ECs to low micromolar concentrations of H2O2 yielded enhanced rates of H2O2 consumption that correlated with HOCl formation and increased eNOS enzyme activity. Hypochlorous Acid myeloperoxidase Homo sapiens