Title : Losartan reduces cigarette smoke-induced airway inflammation and mucus hypersecretion.

Pub. Date : 2021 Jan

PMID : 33532463






2 Functional Relationships(s)
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1 Treatment of HBECs with losartan rescued CS-induced CFTR and BK dysfunction and caused a significant decrease in MUC5AC expression and mucus concentrations, partially by inhibiting TGF-beta signalling. Losartan transforming growth factor beta 1 Homo sapiens
2 In a prospective clinical study, cigarette smokers showed significantly reduced mRNA expression levels of MUC5AC, TGF-beta1, and MMP-9 in the upper airways after 2 months of losartan treatment. Losartan transforming growth factor beta 1 Homo sapiens