Title : CBL mutations drive PI3K/AKT signaling via increased interaction with LYN and PIK3R1.

Pub. Date : 2021 Apr 22

PMID : 33512474






2 Functional Relationships(s)
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1 Signaling adaptor domains of CBL, including the tyrosine-kinase binding domain, proline-rich region, and C-terminal phosphotyrosine sites, were all required for the oncogenic function of CBL mutants. Proline Cbl proto-oncogene Homo sapiens
2 Signaling adaptor domains of CBL, including the tyrosine-kinase binding domain, proline-rich region, and C-terminal phosphotyrosine sites, were all required for the oncogenic function of CBL mutants. Proline Cbl proto-oncogene Homo sapiens