Title : Fucoidan Inhibits NLRP3 Inflammasome Activation by Enhancing p62/SQSTM1-Dependent Selective Autophagy to Alleviate Atherosclerosis.

Pub. Date : 2020

PMID : 33505579






7 Functional Relationships(s)
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1 Fucoidan Inhibits NLRP3 Inflammasome Activation by Enhancing p62/SQSTM1-Dependent Selective Autophagy to Alleviate Atherosclerosis. fucoidan NLR family pyrin domain containing 3 Homo sapiens
2 Fucoidan significantly ameliorated lipid accumulation, attenuated progression of carotid atherosclerotic plaques, deregulated the expression of NLRP3 inflammasome, autophagy receptor p62, and upregulated microtubule-associated protein light chain 3 (LC3)-II/I levels. fucoidan NLR family pyrin domain containing 3 Homo sapiens
3 Mechanistically, fucoidan remarkably inhibited NLRP3 inflammasome activation, which was mostly dependent on autophagy. fucoidan NLR family pyrin domain containing 3 Homo sapiens
4 The inhibitory effects of fucoidan on NLRP3 inflammasome were enhanced by autophagy activator rapamycin (Rapa) and alleviated by autophagy inhibitor 3-methyladenine (3-MA). fucoidan NLR family pyrin domain containing 3 Homo sapiens
5 Fucoidan promoted the colocalization of NLRP3 and p62. fucoidan NLR family pyrin domain containing 3 Homo sapiens
6 Knockdown of p62 and ATG5 by small interfering RNA significantly reduced the inhibitory effects of fucoidan treatment on NLRP3 inflammasome. fucoidan NLR family pyrin domain containing 3 Homo sapiens
7 The data suggest that fucoidan can inhibit NLRP3 inflammasome activation by enhancing p62/SQSTM1-dependent selective autophagy to alleviate atherosclerosis. fucoidan NLR family pyrin domain containing 3 Homo sapiens