Pub. Date : 2020
PMID : 33505579
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Fucoidan Inhibits NLRP3 Inflammasome Activation by Enhancing p62/SQSTM1-Dependent Selective Autophagy to Alleviate Atherosclerosis. | fucoidan | NLR family pyrin domain containing 3 | Homo sapiens |
| 2 | Fucoidan significantly ameliorated lipid accumulation, attenuated progression of carotid atherosclerotic plaques, deregulated the expression of NLRP3 inflammasome, autophagy receptor p62, and upregulated microtubule-associated protein light chain 3 (LC3)-II/I levels. | fucoidan | NLR family pyrin domain containing 3 | Homo sapiens |
| 3 | Mechanistically, fucoidan remarkably inhibited NLRP3 inflammasome activation, which was mostly dependent on autophagy. | fucoidan | NLR family pyrin domain containing 3 | Homo sapiens |
| 4 | The inhibitory effects of fucoidan on NLRP3 inflammasome were enhanced by autophagy activator rapamycin (Rapa) and alleviated by autophagy inhibitor 3-methyladenine (3-MA). | fucoidan | NLR family pyrin domain containing 3 | Homo sapiens |
| 5 | Fucoidan promoted the colocalization of NLRP3 and p62. | fucoidan | NLR family pyrin domain containing 3 | Homo sapiens |
| 6 | Knockdown of p62 and ATG5 by small interfering RNA significantly reduced the inhibitory effects of fucoidan treatment on NLRP3 inflammasome. | fucoidan | NLR family pyrin domain containing 3 | Homo sapiens |
| 7 | The data suggest that fucoidan can inhibit NLRP3 inflammasome activation by enhancing p62/SQSTM1-dependent selective autophagy to alleviate atherosclerosis. | fucoidan | NLR family pyrin domain containing 3 | Homo sapiens |