Title : Targeting and clearance of senescent foamy macrophages and senescent endothelial cells by antibody-functionalized mesoporous silica nanoparticles for alleviating aorta atherosclerosis.

Pub. Date : 2021 Feb

PMID : 33503557






1 Functional Relationships(s)
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1 In invitro models of senescent foamy macrophages and senescent endothelial cells stimulated with oxidized high-density-lipoprotein, the CD9 antibody-modified mesoporous silica nanoparticles exhibit high cellular uptake; reduce the reactive oxygen species level, high-density lipoprotein oxidation, and production of TNF-alpha and IL-6; and attenuate the senescence process, contributing to improved cell viability. mesoporous silica CD9 antigen Mus musculus