Title : Inhibitory effect of PPARγ on NLRP3 inflammasome activation.

Pub. Date : 2021

PMID : 33500734






1 Functional Relationships(s)
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1 Moreover, PPARgamma interfered with NLRP3 inflammasome formation by decreasing NLRP3-ASC and NLRP3-NLRP3 interactions as well as NLRP3-dependent ASC oligomerization, which is mediated through interaction between the PPARgamma DNA-binding domain and the nucleotide-binding and leucine-rich repeat domains of NLRP3. Leucine NLR family pyrin domain containing 3 Homo sapiens