Title : Docosahexaenoic fatty acid reduces the pro-inflammatory response induced by IL-1β in astrocytes through inhibition of NF-κB and AP-1 transcription factor activation.

Pub. Date : 2021 Jan 27

PMID : 33499800






2 Functional Relationships(s)
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1 METHODS AND RESULTS: Activation of the transcription factors NF-kappaB and AP-1 was measured in IL-1beta-treated primary astrocytes incubated with various concentrations of DHA. Dihydroalprenolol Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens
2 DHA treatment inhibited translocation of p65NF-kappaB to the nucleus, significantly lowered p65NF-kappaB protein level and fluorescence of p65NF-kappaB in the nucleus, reduced dose-dependently IkappaB protein phosphorylation, and the binding of the AP-1 transcription factor members (c-Jun/c-Fos) to the specific TPA-response element (TRE) of DNA. Dihydroalprenolol Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens