Title : Network pharmacology and molecular docking reveal the mechanism of Scopoletin against non-small cell lung cancer.

Pub. Date : 2021 Apr 1

PMID : 33497736






2 Functional Relationships(s)
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1 The results of PPI network and molecular docking showed that EGFR, BRAF and AKT1 were the key targets of Scopoletin against NSCLC, which were consistent with the western-blot results. Scopoletin AKT serine/threonine kinase 1 Homo sapiens
2 SIGNIFICANCE: Through network pharmacology, molecular docking and experiments in vitro, Scopoletin was verified to against NSCLC through RAS-RAF-MEK-ERK pathway and PI3K/AKT pathway. Scopoletin AKT serine/threonine kinase 1 Homo sapiens