Pub. Date : 2021 Apr 9
PMID : 33493495
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Saikosaponin A improved depression-like behavior and inhibited hippocampal neuronal apoptosis after cerebral ischemia through p-CREB/BDNF pathway. | saikosaponin D | brain-derived neurotrophic factor | Rattus norvegicus |
| 2 | Administration of Saikosaponin A significantly ameliorated depressive-like behavior, and inhibited neuronal apoptosis, enhanced the level of p-CREB, BDNF and Bcl-2, reduced the level of Bax, Caspase-3 in the hippocampus of PSD rats. | saikosaponin D | brain-derived neurotrophic factor | Rattus norvegicus |
| 3 | These results revealed that Saikosaponin A improved depression-like behavior and inhibited hippocampal neuronal apoptosis after cerebral ischemia, presumably through increasing the expression of BDNF, p-CREB and Bcl-2, as well as decreasing the level of Bax, Caspase-3. | saikosaponin D | brain-derived neurotrophic factor | Rattus norvegicus |