Title : Angiotensin II prevents hypoxic pulmonary hypertension and vascular changes in rat.

Pub. Date : 1988 Mar

PMID : 3348429






3 Functional Relationships(s)
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1 Angiotensin II, a vasoconstrictor, has been previously demonstrated to produce a secondary vasodilatation due to release of prostaglandins. Prostaglandins angiotensinogen Rattus norvegicus
2 The protective effect of angiotensin II was lost when indomethacin was given to block prostaglandin synthesis. Prostaglandins angiotensinogen Rattus norvegicus
3 Thus exogenous angiotensin II infusion prevents chronic hypoxic pulmonary hypertension, associated right ventricular hypertrophy, and vascular changes and blocks acute hypoxic pulmonary hypertension, and this is likely related to its ability to release vasodilator prostaglandins. Prostaglandins angiotensinogen Rattus norvegicus