CPRiL

5 Functional Relationships(s) Download
	Sentence	Compound Name	Protein Name	Organism
1	Moreover, we found that Pb-increased quiescence of HSC critically relied on a synergetic action of Pb and IFNgamma on BM-resident macrophages (MΦ), but not a direct action of Pb on HSC.	Lead	interferon gamma	Homo sapiens
2	Specifically, in steady state, BM-MΦ promoted HSC proliferation; and upon Pb treatment, IFNgamma was induced in the BM, and thereafter Pb in synergism with IFNgamma acted on BM-MΦ to cause BM-MΦ to become suppressive for HSC proliferation, thus leading to increased quiescence of HSC.	Lead	interferon gamma	Homo sapiens
3	Specifically, in steady state, BM-MΦ promoted HSC proliferation; and upon Pb treatment, IFNgamma was induced in the BM, and thereafter Pb in synergism with IFNgamma acted on BM-MΦ to cause BM-MΦ to become suppressive for HSC proliferation, thus leading to increased quiescence of HSC.	Lead	interferon gamma	Homo sapiens
4	Specifically, in steady state, BM-MΦ promoted HSC proliferation; and upon Pb treatment, IFNgamma was induced in the BM, and thereafter Pb in synergism with IFNgamma acted on BM-MΦ to cause BM-MΦ to become suppressive for HSC proliferation, thus leading to increased quiescence of HSC.	Lead	interferon gamma	Homo sapiens
5	Our study suggests that Pb increased the quiescence of HSC via a synergetic action of Pb and IFNgamma on BM-MΦ, which was a previously unrecognized toxicity of Pb.	Lead	interferon gamma	Homo sapiens