Title : The role of orphan receptor GPR139 in neuropsychiatric behavior.

Pub. Date : 2022 Mar

PMID : 33479510






2 Functional Relationships(s)
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1 Remarkably, a number of these behavioral deficits could be rescued by the administration of mu-opioid and D2 dopamine receptor (D2R) antagonists: naltrexone and haloperidol, respectively, suggesting that loss of neuropsychiatric manifestations in mice lacking GPR139 are driven by opioidergic and dopaminergic hyper-functionality. Haloperidol dopamine receptor D2 Mus musculus
2 Remarkably, a number of these behavioral deficits could be rescued by the administration of mu-opioid and D2 dopamine receptor (D2R) antagonists: naltrexone and haloperidol, respectively, suggesting that loss of neuropsychiatric manifestations in mice lacking GPR139 are driven by opioidergic and dopaminergic hyper-functionality. Haloperidol dopamine receptor D2 Mus musculus