Title : Synthesis and Characterization of Rapidly Degrading Polyanhydrides as Vaccine Adjuvants.

Pub. Date : 2020 Jan 13

PMID : 33463223






1 Functional Relationships(s)
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1 In this work, we hypothesized that new copolymers composed of CPTEG and SA would combine the advantages of both monomers in terms of enhanced thermal properties, maintaining antigenicity of encapsulated proteins following nanoparticle synthesis, and superior cellular internalization and activation by APCs, demonstrated by the upregulation of costimulatory markers CD80, CD86, and CD40, as well as the secretion of proinflammatory cytokines IL-6, IL-1beta, and TNF-alpha. copolymers interleukin 6 Homo sapiens