Title : Angiotensin analogues that selectively augment the force of contraction of the isolated heart.

Pub. Date : 1988 Feb

PMID : 3346064






4 Functional Relationships(s)
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1 Replacement of the proline residue in position 7 with alanine reduced the pressor and vascular contractile response to less than 1% of Ang II. Proline angiotensinogen Homo sapiens
2 The results of pharmacological evaluation of various position 7-substituted analogues were as follows: 1) Replacement of proline in position 7 of angiotensin I (Ang I) and Ang II with primary amino acids produced cardiac-specific, positive inotropic properties. Proline angiotensinogen Homo sapiens
3 The results of pharmacological evaluation of various position 7-substituted analogues were as follows: 1) Replacement of proline in position 7 of angiotensin I (Ang I) and Ang II with primary amino acids produced cardiac-specific, positive inotropic properties. Proline angiotensinogen Homo sapiens
4 The results of pharmacological evaluation of various position 7-substituted analogues were as follows: 1) Replacement of proline in position 7 of angiotensin I (Ang I) and Ang II with primary amino acids produced cardiac-specific, positive inotropic properties. Proline angiotensinogen Homo sapiens