Pub. Date : 2021 Mar
PMID : 33454797
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Brain/blood ratios of methadone and ABCB1 polymorphisms in methadone-related deaths. | Methadone | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | The aims of this study were (1) to determine whether brain/blood ratios can assist in the interpretation of methadone findings in fatalities; (2) to examine whether polymorphisms in the gene encoding the P-glycoprotein (also known as multidrug resistance protein 1 (MDR1) or ATP-binding cassette sub-family B member 1 (ABCB1)), which functions as a multispecific efflux pump in the blood-brain barrier, affect brain/blood ratios of methadone. | Methadone | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | The aims of this study were (1) to determine whether brain/blood ratios can assist in the interpretation of methadone findings in fatalities; (2) to examine whether polymorphisms in the gene encoding the P-glycoprotein (also known as multidrug resistance protein 1 (MDR1) or ATP-binding cassette sub-family B member 1 (ABCB1)), which functions as a multispecific efflux pump in the blood-brain barrier, affect brain/blood ratios of methadone. | Methadone | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | Our results suggest that the rs1045642 polymorphisms in ABCB1 may affect methadone concentrations in the brain and its site of action and may be an additional factor influencing methadone toxicity. | Methadone | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 5 | Our results suggest that the rs1045642 polymorphisms in ABCB1 may affect methadone concentrations in the brain and its site of action and may be an additional factor influencing methadone toxicity. | Methadone | ATP binding cassette subfamily B member 1 | Homo sapiens |