Title : High-dose vitamin D during pregnancy and pathway gene polymorphisms in prevention of offspring persistent wheeze.

Pub. Date : 2021 May

PMID : 33453076






3 Functional Relationships(s)
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1 This study aimed to investigate the effect of vitamin D supplementation by maternal and offspring vitamin D receptor (VDR) genotype and GC genotype, encoding vitamin D binding protein (VDBP), in two RCTs. Vitamin D vitamin D receptor Homo sapiens
2 This study aimed to investigate the effect of vitamin D supplementation by maternal and offspring vitamin D receptor (VDR) genotype and GC genotype, encoding vitamin D binding protein (VDBP), in two RCTs. Vitamin D vitamin D receptor Homo sapiens
3 CONCLUSIONS: We found that the effect of high-dose vitamin D supplementation during pregnancy on offspring risk of persistent wheeze was significantly influenced by VDR genotype in the COPSAC2010 RCT, but not VDAART, which may be due to population differences. Vitamin D vitamin D receptor Homo sapiens