Pub. Date : 2021 Jan 15
PMID : 33452414
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In transgenic models selectively expressing amyloid-beta (Abeta), thioflavin S (ThS), a fluorescent dye with beta-sheet binding properties, is widely employed to observe amyloid plaque accumulation. | thioflavin T | amyloid beta (A4) precursor protein | Mus musculus |
| 2 | In transgenic models selectively expressing amyloid-beta (Abeta), thioflavin S (ThS), a fluorescent dye with beta-sheet binding properties, is widely employed to observe amyloid plaque accumulation. | thioflavin T | amyloid beta (A4) precursor protein | Mus musculus |
| 3 | In this study, we investigated the possibility that a commonly used Abeta-expressing AD model mouse, 5XFAD, generates ThS-positive aggregates of beta-sheet structures in addition to Abeta fibrils. | thioflavin T | amyloid beta (A4) precursor protein | Mus musculus |
| 4 | Upon administration of a small molecule that exclusively disaggregates Abeta to 5XFAD mice for six weeks, we found that the reduction level of plaques was smaller in brain sections stained by ThS compared to an anti-Abeta antibody. | thioflavin T | amyloid beta (A4) precursor protein | Mus musculus |
| 5 | Our findings implicate that the use of ThS complicates the quantification of amyloid plaques and the assessment of Abeta-targeting drugs in 5XFAD mice. | thioflavin T | amyloid beta (A4) precursor protein | Mus musculus |