Title : Cryo-EM Structure of K+-Bound hERG Channel Complexed with the Blocker Astemizole.

Pub. Date : 2021 Mar 4

PMID : 33450182






3 Functional Relationships(s)
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1 However, the drug inhibition mechanism remains unclear because of the scarce structural information regarding the drug- and potassium-bound hERG channels. Potassium ETS transcription factor ERG Homo sapiens
2 In this study, we obtained the cryo-EM density map of potassium-bound hERG channel complexed with astemizole, a well-known hERG inhibitor that increases risk of potentially fatal arrhythmia, at 3.5-A resolution. Potassium ETS transcription factor ERG Homo sapiens
3 In this study, we obtained the cryo-EM density map of potassium-bound hERG channel complexed with astemizole, a well-known hERG inhibitor that increases risk of potentially fatal arrhythmia, at 3.5-A resolution. Potassium ETS transcription factor ERG Homo sapiens