Title : Topical Nano-Vesicular Spanlastics of Celecoxib: Enhanced Anti-Inflammatory Effect and Down-Regulation of TNF-α, NF-кB and COX-2 in Complete Freund's Adjuvant-Induced Arthritis Model in Rats.

Pub. Date : 2021

PMID : 33447032






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1 Topical Nano-Vesicular Spanlastics of Celecoxib: Enhanced Anti-Inflammatory Effect and Down-Regulation of TNF-alpha, NF-kB and COX-2 in Complete Freund"s Adjuvant-Induced Arthritis Model in Rats. Celecoxib tumor necrosis factor Rattus norvegicus
2 In the animal model of RA, the celecoxib-loaded spanlastics-containing gel significantly reduced edema circumference and significantly suppressed TNF-alpha, NF-kB and COX-2 levels compared to the niosomes-containing gel, the marketed diclofenac sodium gel, and unprocessed celecoxib-loaded gel. Celecoxib tumor necrosis factor Rattus norvegicus