Pub. Date : 2021 Apr
PMID : 33446524
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Taken together, these data suggest that candesartan acyl-beta-D-glucuronide is actively transported by OATPs into hepatocytes, and drug-drug interactions may occur with coadministration of candesartan and CYP2C8 substrates including paclitaxel as a result of the inhibition of CYP2C8 function. | candesartan | cytochrome P450 family 2 subfamily C member 8 | Homo sapiens |
| 2 | Taken together, these data suggest that candesartan acyl-beta-D-glucuronide is actively transported by OATPs into hepatocytes, and drug-drug interactions may occur with coadministration of candesartan and CYP2C8 substrates including paclitaxel as a result of the inhibition of CYP2C8 function. | candesartan | cytochrome P450 family 2 subfamily C member 8 | Homo sapiens |
| 3 | Significance Statement This study demonstrates that the acyl glucuronidation of candesartan to form candesartan acyl-beta-D-glucuronide enhances CYP2C8 inhibition while exerting minimal effects on CYP3A4, OATP1B1, and OATP1B3. | candesartan | cytochrome P450 family 2 subfamily C member 8 | Homo sapiens |
| 4 | Thus, candesartan acyl-beta-D-glucuronide might represent a potential mediator of drug-drug interactions between candesartan and CYP2C8 substrates, such as paclitaxel, in clinical settings. | candesartan | cytochrome P450 family 2 subfamily C member 8 | Homo sapiens |