Pub. Date : 2021 Apr 1
PMID : 33443933
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Tranexamic acid rapidly inhibits fibrinolysis, yet transiently enhances plasmin generation in vivo. | Tranexamic Acid | plasminogen | Homo sapiens |
| 2 | Tranexamic acid (TXA) is a lysine analogue that inhibits plasmin generation and has been used for decades as an antifibrinolytic agent to reduce bleeding. | Tranexamic Acid | plasminogen | Homo sapiens |
| 3 | Tranexamic acid (TXA) is a lysine analogue that inhibits plasmin generation and has been used for decades as an antifibrinolytic agent to reduce bleeding. | Tranexamic Acid | plasminogen | Homo sapiens |
| 4 | Recent reports have indicated that TXA can paradoxically promote plasmin generation. | Tranexamic Acid | plasminogen | Homo sapiens |
| 5 | In contrast, PAP complex formation, representing plasmin generation, was unexpectedly enhanced in the plasma of patients administered TXA at the EOS time point. | Tranexamic Acid | plasminogen | Homo sapiens |
| 6 | Our findings demonstrate that TXA can actually augment PAP complex formation, consistent with an increase in plasmin generation in vivo despite the fact that it blocks fibrinolysis within 30 min. | Tranexamic Acid | plasminogen | Homo sapiens |