Pub. Date : 2021 Jan 13
PMID : 33435886
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Iron overload adversely effects bone marrow haematogenesis via SIRT-SOD2-mROS in a process ameliorated by curcumin. | Curcumin | superoxide dismutase 2 | Homo sapiens |
| 2 | Curcumin treatment ameliorated peripheral blood cells generation, enhanced SIRT3 activity, decreased SOD2 acetylation, inhibited mROS production, and suppressed iron loading-induced autophagy. | Curcumin | superoxide dismutase 2 | Homo sapiens |
| 3 | CONCLUSIONS: Our results suggest that curcumin exerts a protective effect on bone marrow by reducing mROS-stimulated autophagic cell death in a manner dependent on the SIRT3/SOD2 pathway. | Curcumin | superoxide dismutase 2 | Homo sapiens |