Title : Halofuginone regulates keloid fibroblast fibrotic response to TGF-β induction.

Pub. Date : 2021 Mar

PMID : 33433355






1 Functional Relationships(s)
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1 Here we analyze the antifibrotic mechanisms of Halofuginone (HF), a drug reportedly able to inhibit the TGF-beta1-Smad3 pathway and to attenuate collagen synthesis, in an in-vitro keloid model using patient-derived Keloid Fibroblasts (KFs) isolated from fibrotic tissue collected during the "Scar Wars" clinical study (NCT NCT03312166). halofuginone SMAD family member 3 Homo sapiens