Pub. Date : 2020
PMID : 33425926
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | DNA damage response (DDR) and apoptosis are reported to be involved in the pathogenesis of many neurodegenerative diseases including polyglutamine (polyQ) disorders, such as Spinocerebellar ataxia type 3 (SCA3) and Huntington"s disease (HD). | polyglutamine | ataxin 3 | Homo sapiens |
| 2 | DNA damage response (DDR) and apoptosis are reported to be involved in the pathogenesis of many neurodegenerative diseases including polyglutamine (polyQ) disorders, such as Spinocerebellar ataxia type 3 (SCA3) and Huntington"s disease (HD). | polyglutamine | ataxin 3 | Homo sapiens |
| 3 | Consistently, an increasing body of studies provide compelling evidence for the crucial roles of ATX3, whose polyQ expansion is defined as the cause of SCA3, in the maintenance of genome integrity and regulation of apoptosis. | polyglutamine | ataxin 3 | Homo sapiens |
| 4 | The polyQ expansion in ATX3 seems to affect its physiological functions in these distinct pathways. | polyglutamine | ataxin 3 | Homo sapiens |