Pub. Date : 2021 Feb
PMID : 33421702
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | All but two patients with paradoxical reactions to lamotrigine were diagnosed with juvenile myoclonic epilepsy (JME), otherwise, the clinical and electroencephalographic characteristics of patients with paradoxical reactions did not differ. | Lamotrigine | myoclonic epilepsy, juvenile, 2 | Homo sapiens |
| 2 | At treatment start, the estimated risk of a paradoxical reaction to lamotrigine was 7.9 % in JME patients (n = 190). | Lamotrigine | myoclonic epilepsy, juvenile, 2 | Homo sapiens |
| 3 | JME), the estimated risk of clinically relevant seizure aggravation under treatment with lamotrigine was 3.7 % (1.8 % for zonisamide and 0.8 % for levetiracetam). | Lamotrigine | myoclonic epilepsy, juvenile, 2 | Homo sapiens |
| 4 | In conclusion, clinical significant aggravation of seizure frequency is common in lamotrigine-treated JME patients but rare in patients with other GGE subsyndromes or under treatment with other recommended anti-seizure medication. | Lamotrigine | myoclonic epilepsy, juvenile, 2 | Homo sapiens |